pI: 10.1171 |
Length (AA): 585 |
MW (Da): 66335 |
Paralog Number:
0
Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There is 1 model calculated for this protein. More info on
this model, including the
model itself is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
42 | 289 | 5zyu (A) | 99 | 336 | 29.00 | 0 | 0.97 | 1.03496 | 0.12 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_133450)
Species | Accession | Gene Product |
---|---|---|
Brugia malayi | Bm1_24160 | Protein C20orf72 homolog |
Caenorhabditis elegans | CELE_C27H6.9 | Protein C27H6.9 |
Echinococcus granulosus | EgrG_000211400 | hypothetical protein |
Echinococcus multilocularis | EmuJ_000211400 | conserved hypothetical protein |
Homo sapiens | ENSG00000125871 | mitochondrial genome maintenance exonuclease 1 |
Loa Loa (eye worm) | LOAG_04860 | hypothetical protein |
Mus musculus | ENSMUSG00000027424 | mitochondrial genome maintainance exonuclease 1 |
Onchocerca volvulus | OVOC12119 | Mitochondrial genome maintenance exonuclease 1 homolog |
Schistosoma japonicum | Sjp_0080820 | IPR001220,Legume lectin, beta domain,domain-containing |
Schistosoma mansoni | Smp_097280 | hypothetical protein |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 23.5% | 247 aa | Compounds | References |
Rattus norvegicus | Tyrosine-protein kinase Lyn | 512 aa | 27.0% | 426 aa | Compounds | References |
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 25.6% | 156 aa | Compounds | References |
Rattus norvegicus | Jak1 protein | 210 aa | 28.8% | 205 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 26.0% | 269 aa | Compounds | References |